Jun 222020
 
Jonna Ocampos headshot

Jonna Ocampo, former INBRE student researcher at Leeward Community College in 2014-2015, will be pursuing her M.D. at the Ross University School of Medicine beginning this summer. Her experience working on the synthesis and biological evaluation of chalconoid antimicrobials with Dr. Bradley Ashburn and Dr. Helmut Kae inspired her to earn a Master’s degree in Medical Sciences with a concentration in Molecular Medicine at the University of South Florida.

Jonna has been awarded numerous honors such as the NASA Florida Space Grant Consortium Fellowship for her work on Transposon Expression Changes Induced by Simulated Microgravity and has presented at national and international conferences including the United Nations Expert Meeting on Human Space Technology in Vienna, Austria and 4th Mexican Congress of Medicine and Space Health, in Mexico City, Mexico.

Her former INBRE supervisor Bradley Ashburn says, “I have had the great pleasure to keep in contact with Jonna over the years and witness her growth into a high-achieving biomedical researcher. She works relentlessly to further the boundaries of science (literally speaking, she has performed experiments in microgravity space flights). Jonna embodies the spirit and success of the Hawaii INBRE program and will continue to make an impact as she pursues her dream to be a physician.”

Jun 222020
 
Ashley Fukuchi headshot

Ashley Fukuchi, University of Hawaii at Hilo

Congratulations to Ashley Fukuchi for being a recipient of this year’s 2020-2021 AFPE Gateway award!!

The American Foundation for Pharmaceutical Education (AFPE) is a non-profit organization that provides scholarships and grants to aspiring researchers and academics to be able to conduct novel research in the pharmaceutical sciences arena that will impact the future of healthcare and patient outcomes.  “The primary goal of the Gateway to Research Scholarship program is to help students understand the importance of research by enabling them to apply that knowledge to improve their clinical goals” (source: http://afpepharm.org/wp-content/uploads/2018/08/2019-Gateway-Description.pdf).   Ashley was selected from a highly selective pool of applicants.

Ashley has received INBRE SRE stipends support for conducting research in Leng Chee Chang’s laboratory in the past.

Mentor: Leng Chee Chang, PhD, MS, The Daniel K. Inouye College of Pharmacy, UH Hilo, Hawaii

Collaborator: Jennifer R. Honda, PhD, National Jewish Health, Denver, Colorado

Research Title: Evaluation of natural products-derived from medicinal plants as potential antimicrobial agents against non-tuberculosis mycobacteria

In recent years, the number of nontuberculous mycobacterial pulmonary disease cases have increased globally, surpassing tuberculosis in some countries. Nontuberculous mycobacteria (NTM) is common in the environment found in water and soil. People can come into contact with NTM bacteria through simple, daily activities, such as showering or gardening. Exposure to this aerosolized bacteriacan leads to NTM entering the lungs. In some people, the bacteria infects the airways and lung tissue leading to increased risk of getting NTM lung disease (NTMLD). Hawai‘i has been identified as the state with the highest prevalence of NTMLD when compared with the national average, and NTM is found to be common in the Hawaii environment. Epidemiological studies show Mycobacterium chimaera, a slow-growing NTM and member of the Mycobacterium avium complex (MAC), predominates in the Hawaiian environment and is the most frequently isolated NTM from lung samples among Hawai‘i NTM patients. NTM is often associated with biofilm formation, contributing to antibiotic resistance. Treatment for NTMLD is challenging because treatment times are lengthy, a combination of drugs are needed, and relapses following therapy are common resulting in substantial morbidity and mortality. In addition, FDA-approved drugs that specifically treat NTMLD does not exist at the current time. Thus, there is a need for novel treatment approaches for NTM.

This project posits that phytochemicals obtained from Hawaiian medicinal plants could represent novel treatment approaches. Traditional medicine has a long history of treating human diseases, including respiratory and lung infections. For example, active ingredients extracted from the medicinal plant, ‘uhaloa, is used to treat sore throat, asthma, and cough. Morinda citrifolia (fermented noni ) has been used in traditional medicine for treating asthma, cough, tuberculosis, and infectious diseases. This application proposes to examine traditional medicinal sources as antimycobacterial agents to control NTM.  We hypothesize that natural products from Hawaiian medicinal plants may show antimicrobial activity against Hawai‘ian derived NTM isolates.

The project goal is 1) Test the anti-NTM activity of several medicinal plant extracts against M. chimaera. 2) To identify major antimicrobial compounds from one most promising crude extract that might be found in aim 1. This study will lead to the identification of promising leads. Extracts and possibly compounds will be subjected to further mechanisms of action in vitro studies.

Research Topic Areas:

  1. Antimicrobial and antioxidant activity of natural products against community-acquired Staphylococcus aureus, methicillin-resistant Staphylococcus aureus (MRSA), and bacteria infections.
  2. Antimycobacterial activity of Hawaiian Medicinal Plants and marine algae against Nontuberculous Mycobacteria such as Mycobacterium chimaera isolated from Hawaii.
  3. Phytochemical evaluation of tropical plants/crops for bioactive components as potential functional foods.
  4. Evaluation of natural products as anticancer agents (NF-kB as Molecular Targets). To isolate and identify natural products-derived from medicinal plants and marine algae with potential anticancer activity.

Dec 162019
 
Terezie Cernosek from Chaminade University at the NIH IDeA Western Regional Conference October 2019

INBRE Undergraduate student, Terezie Cernosek, published her first scientific paper titled, “Volatile Organic Compound Profiling from Postmortem Microbes using Gas Chromatography-Mass Spectrometry,” under the mentorship of Dr. Katelynn Perrault, Assistant Professor of Forensic Sciences and Chemistry at Chaminade University of Honolulu. Ms. Cernosek was a participant in the INBRE SRE program of Spring 2018 and was one of four Top Poster scores at the 2019 Biomedical Sciences & Health Disparities Symposium, Undergraduate Division. As a top poster score, INBRE sponsored her trip to the NIH IDeA Western Regional Conference in Las Vegas, NV, on October 6-9, 2019, where she was able to present her poster amongst her peers who reside in other IDeA states.

Dec 162019
 
Marilyn Yamamoto in Dr. Li Tao's Lab
Tao Lab at the 2019 Biomedical Sciences & Health Disparities Symposium. (L-R) INBRE Undergraduate students Joshua Lawcock, Arash Vahidi, Marilyn Yamamoto, and Kathleen Shon, with their mentor, Dr. Li Tao.

Marilyn Yamamoto, INBRE Undergraduate at the University of Hawaii at Hilo, has been accepted into medical school at Drexel College of Medicine, Philadelphia, PA. Ms. Yamamoto participated in the INBRE Student Research Experience as an INBRE Associate in the Spring 2019 semester under the mentorship of Dr. Li Tao, Associate Professor in Biology. This is another great example of how INBRE facilitates students’ career pathways in the biomedical field. INBRE program wishes Marilyn much success in her academic career at Drexel!

Nov 042019
 
INBRE Faculty, Staff, and Students

The Top 4 INBRE IV Poster Presenters from the 2019 Biomedical Sciences & Health Disparities Symposium held on April 26, 2019 at the University of Hawaii, John A. Burns School of Medicine, attend the NIH IDeA Western Regional Conference on October 7-9, 2019 in Las Vegas, Nevada, to showcase their scientific posters on October 7-9, 2019. More photos of the event are available on Flickr.

Sep 182019
 

On May 21-22, 2019, the EPSCoR/IDeA Foundation, National Association of IDeA Principal Investigators (NAIPI), and Van Scoyoc Associates hosted nine students for the second “Take Your IDeA Science to Capitol Hill” day. Ms. Destiny Mabalot, INBRE Undergraduate Student from the University of Hawaii at West Oahu, was selected as the Hawaii INBRE student ambassador. The purpose of the visit was to provide students the opportunity to illustrate the importance of their IDeA INBRE experiences and thank their senators and representatives for supporting the EPSCoR/IDeA programs. For more details, read the EPSCoR/IDeA Fall 2019 Newsletter here.

Aug 232019
 

Nineteen INBRE students at Leeward Community College presented a variety of their summer research projects on August 8, 2019.

May 012019
 

The INBRE Program Meeting and Biomedical Sciences & Health Disparities Symposium on April 26, 2019, was a great success with students expanding upon their academic activities. We had many faculty comments about the impressive quality of research and the manner of professional presentation – INBRE students you did yourself proud!

The scores are in for the Top 4 INBRE Undergraduate Student Poster Presentations. These students are invited to attend and participate in the NIH IDeA Western Regional Conference in Las Vegas, Nevada, on October 6 – 9, 2019. Registration, airfare, and lodging expenses will be covered by the INBRE program. The Top 4 scores are:

  • Terezie Cernosek, Chaminade University
  • Yaeko Tagami, University of Hawaii at Hilo
  • Nandini Bickel, Windward Community College
  • Maria Steadmon, University of Hawaii at Hilo

Well done and congratulations to all participants! We look forward to having you in the Student Research Experience program next semester or seeing you at graduation! Much success to you all.

Apr 092019
 

A special ‘Thank You’ to all of you who participated in the INBRE Logo Contest. Who knew we had such a talented group of artists! We truly appreciate each and every one of you who took the time from your busy schedule to create some very unique and imaginative designs. The committee was impressed with the submissions overall, which really took the program’s key concepts to heart. So, as you can imagine, it was difficult to choose just one. With that being said….

Congratulations to
~ Diana Le ~
INBRE Student from Leeward Community College

As the winner of the INBRE Logo Contest, Diana will receive an award at the INBRE Program Meeting on April 26, 2019. Together with her design, skillset in Adobe Illustrator, and collaboration with the INBRE Logo Committee, we are very excited to share the new INBRE logo with all of you.

The new logo is available in two formats: Portrait (text on bottom) and Landscape (text on right). If you are planning to present in this year’s Biomedical Symposium, please contact us at inbre@hawaii.edu to obtain the logo files. As a reminder, the poster printing deadline to UH Manoa PBRC is Friday, April 19, 2019.

Top INBRE III Poster Presenters attend the NISBRE scientific meeting on June 24-26, 2018

 SRE Student Accomplishments, Student Research Experience  Comments Off on Top INBRE III Poster Presenters attend the NISBRE scientific meeting on June 24-26, 2018
Jul 062018
 
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