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lange
Ingo Koomoa-Lange, Ph.D.
Instructor
Department of Pharmaceutical Sciences
The Daniel K. Inouye College of Pharmacy
University of Hawaii at Hilo

Antineoplastic drug induced calcium signaling regulates drug resistance in Neuroblastoma progenitor-like subpopulations

The PIs research focuses on understanding how ion channel signaling steers physiological and pathophysiological processes within and between cells. The research thereby concentrates on identifying the molecular components that regulate the spatial and temporal dynamics of calcium signals between the plasma membrane and organelles, and the resulting physiological consequences (e.g. regulation of transcription, reprograming the cell fate including cell deaths). One of the main areas of research is to understand these processes and their contribution to the malignant progression and the development of multi-drug resistance in Neuroblastoma. Another area of research investigates the dynamic signaling cascades that are induced by pathogens and pathochemical stimuli in the cells of the innate immune system. Recently, the PI has been working on the pathways that are shared among the two fields, pediatric oncology and innate immunology, and thereby studies the interplay of innate immune cells in the tumor microenvironment. The laboratory uses a combination of high-content imaging, genomic analysis, as well as molecular, biochemical & biophysical techniques.

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